Clinical Translation of a Newly Discovered Transcriptional Fusion Involving the Multidrug Resistance Transporter (Abcb1) in Recurrent Drug Resistant Ovarian Cancer

Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer

EL Christie, S Pattnaik, J Beach, A Copeland, N Rashoo, S Fereday, J Hendley, K Alsop, SL Brady, G Lamb, A Pandey, A deFazio, H Thorne, A Bild, DDL Bowtell

2019-12-01

ABCB1 encodes Multidrug Resistance protein (MDR1), an ATP-binding cassette member involved in the cellular efflux of chemotherapeu..

Acquired chemotherapy resistance in ovarian cancer

EL Christie, DDL Bowtell

2017-11-01

Most women diagnosed with high-grade serous ovarian cancer (HGSC) develop recurrent disease and chemotherapy resistance, despite i..